Risk factor

In epidemiology, a risk factor is a variable associated with an increased risk of disease or infection. Sometimes, determinant is also used, being a variable associated with either increased or decreased risk.

1 Correlation vs causation
2 Terms of description
3 Example
4 General determinants
5 Risk marker
6 History
7 See also
8 References
9 Further reading

Correlation vs causation

Risk factors or determinants are correlational and not necessarily causal, because correlation does not prove causation. For example, being young cannot be said to cause measles, but young people have a higher rate of measles because they are less likely to have developed immunity during a previous epidemic. Statistical methods are frequently used to assess the strength of an association and to provide causal evidence (for example in the study of the link between smoking and lung cancer). Statistical analysis along with the biological sciences can establish that risk factors are causal. Some prefer the term risk factor to mean causal determinants of increased rates of disease, and for unproven links to be called possible risks, associations, etc.

Terms of description

Mainly taken from risk factors for breast cancer, risk factors can be described in terms of, for example:

Relative risk, such as "A woman is more than 100 times more likely to develop breast cancer in her 60s than in her 20s.^[1]"
Fraction of incidences occurring in the group having the property of or being exposed to the risk factor, such as "99% of breast cancer cases are diagnosed in women^[2]"
Increase in incidence in the exposed group, such as "each daily alcoholic beverage increases the incidence of breast cancer by 11 cases per 1000 women^[3]"
Hazard ratio, such as "an increase in both total and invasive breast cancers in women randomized to receive estrogen and progestin for an average of 5 years, with a hazard ratio of 1.24 compared to controls"^[4]

Example

The following example of a risk factor is described in terms of the relative risk it confers, which is evaluated by comparing the risk of those exposed to the potential risk factor to those not exposed. Let's say that at a wedding, 74 people ate the chicken and 22 of them were ill, while of the 35 people who had the fish or vegetarian meal only 2 were ill. Did the chicken make the people ill?

$Risk = \frac {\mbox{number of persons experiencing event (food poisoning)}} {\mbox{number of persons exposed to risk factor (food)}}$

So the chicken eaters' risk = 22/74 = 0.297
And non-chicken eaters' risk = 2/35 = 0.057.

Those who ate the chicken had a risk over five times as high as those who did not, that is, a relative risk of more than five. This suggests that eating chicken was the cause of the illness, but this is not proof.

General determinants

The probability of an outcome usually depends on an interplay between multiple risk factors. When performing epidemiological studies to evaluate one or more determinants for a specific outcome, the other determinants may act as confounding factors, and need to be controlled for, e.g. by stratification. The potentially confounding determinants varies with what outcome is studied, but the following general risk factors are common to most epidemiological associations, and are the determinants most commonly controlled for in epidemiological studies:

Age
Sex or gender
Ethnicity

Other less commonly adjusted for possible confounders include:

Social status/income
Geographic location
Genetic predisposition
Gender identity
Occupation
Sexual orientation
Level of chronic stress
Diet
Level of physical exercise
Alcohol consumption and tobacco smoking
Other social determinants of health

Risk marker

A risk marker is a variable that is quantitatively associated with a disease or other outcome, but direct alteration of the risk marker does not necessarily alter the risk of the outcome.

History

The term "risk factor" was first coined by former Framingham Heart Study Director Dr. William B. Kannel a 1961 article in Annals of Internal Medicine.^[5]

References

^ Margolese, Richard G, Bernard Fisher, Gabriel N Hortobagyi, and William D Bloomer (2000). "118". In Bast RC, Kufe DW, Pollock RE, et al.. Cancer Medicine (e.5 ed.). Hamilton, Ontario: B.C. Decker. ISBN 1-55009-113-1. http://www.ncbi.nlm.nih.gov/books/NBK20900/#A29677. Retrieved 27 January 2011.
^ Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN (July 2004). "Breast carcinoma in men: a population-based study". Cancer 101 (1): 51–7. doi:10.1002/cncr.20312. PMID 15221988.
^ Allen NE, Beral V, Casabonne D, et al. (March 2009). "Moderate alcohol intake and cancer incidence in women". Journal of the National Cancer Institute 101 (5): 296–305. doi:10.1093/jnci/djn514. PMID 19244173.
^ Heiss, G.; Wallace, R.; Anderson, G. L.; Aragaki, A.; Beresford, S. A. A.; Brzyski, R.; Chlebowski, R. T.; Gass, M. et al. (2008). "Health Risks and Benefits 3 Years After Stopping Randomized Treatment with Estrogen and Progestin". JAMA: the Journal of the American Medical Association 299 (9): 1036. doi:10.1001/jama.299.9.1036. edit
^ http://www.forbes.com/sites/larryhusten/2011/08/23/william-kannel-former-director-of-the-framingham-heart-study-dead-at-87/